pI: 7.0793 |
Length (AA): 629 |
MW (Da): 71893 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
49 | 327 | 5ko2 (A) | 340 | 615 | 22.00 | 0.0000015 | 0.99 | 0.601061 | 0.84 |
49 | 270 | 4pl0 (A) | 302 | 512 | 28.00 | 0.00001 | 0.5 | 0.392341 | 1.35 |
50 | 327 | 5ko2 (A) | 341 | 615 | 24.00 | 0.00000024 | 0.96 | 0.621371 | 0.81 |
91 | 619 | 5zxd (A) | 3 | 537 | 42.00 | 0 | 1 | 1.13832 | 0.34 |
93 | 619 | 5zxd (B) | 5 | 537 | 45.00 | 0 | 1 | 1.29424 | -0.22 |
404 | 598 | 4yer (A) | 3 | 211 | 22.00 | 0 | 1 | 0.576316 | -0.68 |
405 | 605 | 3tif (A) | 1 | 227 | 23.00 | 0.00000019 | 1 | 0.546055 | -0.44 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128616)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G60790 | ABC transporter F family member 1 |
Brugia malayi | Bm1_18510 | ATP-binding cassette, sub-family F, member 2 |
Candida albicans | CaO19.9729 | ATP-binding cassette protein similar to S. cerevisiae YER036C |
Candida albicans | CaO19.2183 | ATP-binding cassette protein similar to S. cerevisiae YER036C |
Caenorhabditis elegans | CELE_T27E9.7 | Protein ABCF-2 |
Dictyostelium discoideum | DDB_G0284047 | ABC transporter-related protein |
Drosophila melanogaster | Dmel_CG9281 | CG9281 gene product from transcript CG9281-RB |
Homo sapiens | ENSG00000033050 | ATP-binding cassette, sub-family F (GCN20), member 2 |
Leishmania braziliensis | LbrM.19.1110 | ABC transporter, putative |
Leishmania donovani | LdBPK_190800.1 | ATP-binding cassette protein subfamily F, member 2, putative |
Leishmania infantum | LinJ.19.0800 | ATP-binding cassette protein subfamily F, member 2, putative |
Leishmania major | LmjF.19.0800 | ATP-binding cassette protein subfamily F, member 2, putative |
Leishmania mexicana | LmxM.19.0800 | ABC transporter, putative |
Loa Loa (eye worm) | LOAG_07759 | ATP-binding cassette |
Mus musculus | ENSMUSG00000028953 | ATP-binding cassette, sub-family F (GCN20), member 2 |
Oryza sativa | 4346343 | Os08g0564100 |
Oryza sativa | 4347924 | Os09g0572400 |
Saccharomyces cerevisiae | YER036C | ATP-binding cassette family ATPase ARB1 |
Schistosoma japonicum | Sjp_0306880 | ATP-binding cassette sub-family F member 2, putative |
Schistosoma japonicum | Sjp_0218580 | ko:K06185 ATP-binding cassette, sub-family F, member 2, putative |
Schistosoma mansoni | Smp_040540 | ATP-dependent transporter |
Schmidtea mediterranea | mk4.017271.00 | ATP-binding cassette sub-family F member 2 |
Schmidtea mediterranea | mk4.001072.00 | |
Schmidtea mediterranea | mk4.009907.00 | |
Trypanosoma brucei gambiense | Tbg972.10.18970 | ABC transporter, putative |
Trypanosoma brucei | Tb11.v5.0748 | ABC transporter, putative |
Trypanosoma brucei | Tb927.10.15530 | ABC transport system ATP-binding protein, putative |
Trypanosoma congolense | TcIL3000_10_13320 | ABC transporter, putative |
Trypanosoma cruzi | TcCLB.508897.30 | ABC transport system ATP-binding protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.15530 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.15530 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.15530 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.15530 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
YER036C | Saccharomyces cerevisiae | inviable | yeastgenome |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.